'lack of moral shame and dread', 

are two of the 4 disadvantageous factors associated with all karmically disadvantageous states of consciousness, the two others being restlessness (uddhacca) and delusion (moha). Cf. Tab. II.

"There are two sinister things, namely, lack of moral shame and dread, etc." (A.II.6). "Not to be ashamed of what one should be ashamed of; not to be ashamed of evil, disadvantageous things: this is called lack of moral shame" (Pug. 59). "Not to dread what one should dread ... this is called lack of moral dread (Pug. 60).